Montreal Neurological Institute
Molecular Neurogenetics
McGill University
 

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Patient with Heteroplasmic mtDNA deletion

  1. Ragged red fibres as shown by Modified Gomori Trichrome staining.
  2. Paracrystalline inclusions found in mitochondria of ragged red fibres.
  1. Fibres are negative for cytochrome c oxidase (dots).
  2. Fibres negative for cytochrome c oxidase have an accumulation of deleted mtDNA.